CircleDNA is operated by Prenetics Limited, a leading genomics-driven health sciences company with its own global laboratories and partner laboratories. Every sample we receive is treated with care according to international quality standards and effective protocols for handling samples and DNA test processes. Read on for details on what happens to your DNA sample at every step when it arrives at our laboratory.
Step 1: Inventory and Visual Inspection
Upon arrival at one of our laboratories, your sample is entered into the lab's inventory system, and this triggers a notification email to inform you that we have received your DNA sample. Our lab technicians visually inspect your sample. Occasionally, a sample may not pass this step due to reasons such as leakage during transit. In such cases, we will contact you and ship a replacement kit to collect a new sample. Samples that have not been registered will require you to register first before we can ship a replacement kit.
Step 2: DNA Extraction
After passing the visual inspection, DNA is extracted from your sample. Your cells are broken open, and genomic DNA is extracted from buccal cells. The extracted DNA is then fragmented and prepared into Next-Generation Sequencing (NGS) libraries. If satisfactory results cannot be yielded from the first and second attempt at DNA extraction, we will contact you and ship a replacement kit to collect a new sample.
Step 3: DNA Analysis
Samples submitted for the CircleDNA tests are analyzed using Next Generation Sequencing (NGS), which can read your DNA and analyze over 3 million data points. Circle carries out analysis for up to two attempts if the first attempt fails. If a second attempt at analysis also fails, we will contact you and ship a replacement kit to collect a new sample.
Step 4: Report Generation
Upon successful analysis of your DNA, your results are interpreted to generate a user-friendly and actionable personalized report just for you!
All Circle test samples are processed with international quality standards and effective protocols for handling samples and DNA test processes. We have had external validation completed by The Croucher Laboratory for Human Genomics (CLHG), which has proven analytical accuracy of 99.9%.